Article

Human PrP E219K as a new and promising substrate for RT-QuIC amplification of human prion strains: a first step towards strain discrimination

2024-07-31

Abstract excerpt

<h4>Summary</h4> Prion diseases are fatal neurodegenerative diseases that affect mammals through the transconformation of a host protein, the prion protein (PrP), into a toxic and pathogenic conformer termed PrP Sc . Until now, the diagnosis is only confirmed with a post-mortem histology study of the central nervous system. Among the methods to detect the etiological agent, in vitro amplification techniques hav...

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Literature Corpus work: 2fa54310-a962-571a-89dd-cc0c9391e3c3
DOI: 10.1101/2024.07.31.605973

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