Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of donor genotype in RT-QuIC seeding activity of chronic wasting disease prions using human and bank vole substrates.

PloS one - 1 Jan 2020

Hwang Soyoun, Greenlee Justin J, Nicholson Eric M

Abstract excerpt

Chronic wasting disease is a transmissible spongiform encephalopathy of cervids. This fatal neurodegenerative disease is caused by misfolding of the cellular prion protein (PrPC) to pathogenic conformers (PrPSc), and the pathogenic forms accumulate in the brain and other tissues. Real-time Quaking Induced Conversion (RT-QuIC) can be used for the detection of prions and for prion strain discrimination in a variety...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arvicolinae
Share to Deer
Share to Immunoassay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Prion Proteins

Share to PrPC Proteins

Share to PrPSc Proteins

Share to Substrate Specificity

Share to Wasting Disease, Chronic

Source

Open in PubMed Open full text

Identifiers

PMID: 31910440
DOI: 10.1371/journal.pone.0227487
PMCID: PMC6946595

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of donor genotype in RT-QuIC seeding activity of chronic wasting disease prions using human and bank vole substrates.PMID 31910440Read ↗

Estimating chronic wasting disease susceptibility in cervids using real-time quaking-induced conversion.Semantic proximity Read ↗

Human PrP E219K as a new and promising substrate for RT-QuIC amplification of human prion strains: a first step towards strain discriminationSemantic proximity Read ↗

Detection and Discrimination of Classical and Atypical L-Type Bovine Spongiform Encephalopathy by Real-Time Quaking-Induced ConversionSemantic proximity Read ↗

Destabilizing polymorphism in cervid prion protein hydrophobic core determines prion conformation and conversion efficiency.Semantic proximity Read ↗

Detection by real-time quaking-induced conversion (RT-QuIC), ELISA, and IHC of chronic wasting disease prion in lymph nodes from Pennsylvania white-tailed deer with specific PRNP genotypes.Semantic proximity Read ↗

Chronic wasting disease (CWD) prion detection in blood from pre-symptomatic white-tailed deer harboring PRNP polymorphic variants.Semantic proximity Read ↗

Diagnostic and prognostic value of human prion detection in cerebrospinal fluid.Semantic proximity Read ↗

Characteristic CSF prion seeding efficiency in humans with prion diseases.Semantic proximity Read ↗

Clinical Use of Improved Diagnostic Testing for Detection of Prion Disease.Semantic proximity Read ↗

RT-QuIC amplification of CWD prions in winter ticks ( <i>Dermacentor albipictus</i> ) collected from North American elk ( <i>Cervus canadensis</i> ) in a CWD-endemic areaSemantic proximity Read ↗

Trajectories of neurodegeneration and seed amplification biomarkers prior to disease onset in individuals at risk of prion diseaseSemantic proximity Read ↗

Prion strain mutation determined by prion protein conformational compatibility and primary structure.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.