Article

Elucidation and control of low and high active populations of alkaline phosphatase molecules for quantitative digital bioassay

2020-10-18

Abstract excerpt

Alkaline phosphatase (ALP), a homo-dimeric enzyme has been widely used in various bioassays as disease markers and enzyme probes. Recent advancements of digital bioassay revolutionized ALP-based diagnostic assays as seen in rapid growth of digital ELISA and the emerging multiplex profiling of single-molecule ALP isomers. However, the intrinsic heterogeneity found among ALP molecules hampers the ALP-based quantitat...

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Literature Corpus work: d4b151f1-cc9c-549d-b6d6-00819d74cd96
DOI: 10.1101/2020.10.18.336891

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