Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanistic and Evolutionary Insights from Comparative Enzymology of Phosphomonoesterases and Phosphodiesterases across the Alkaline Phosphatase Superfamily.

Journal of the American Chemical Society - 2 Nov 2016

Sunden Fanny, AlSadhan Ishraq, Lyubimov Artem Y, Ressl Susanne, Wiersma-Koch Helen, Borland Jamar, Brown Clayton L, Johnson Tory A, Singh Zorawar, Herschlag Daniel

Abstract excerpt

Naively one might have expected an early division between phosphate monoesterases and diesterases of the alkaline phosphatase (AP) superfamily. On the contrary, prior results and our structural and biochemical analyses of phosphate monoesterase PafA, from Chryseobacterium meningosepticum, indicate similarities to a superfamily phosphate diesterase [Xanthomonas citri nucleotide pyrophosphatase/phosphodiesterase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biocatalysis
Share to Catalytic Domain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Hydrolysis

Share to Phosphoric Diester Hydrolases

Share to Phosphoric Monoester Hydrolases

Share to Substrate Specificity

Share to Xanthomonas

Source

Open in PubMed Open full text

Identifiers

PMID: 27670607
DOI: 10.1021/jacs.6b06186
PMCID: PMC5096464

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanistic and Evolutionary Insights from Comparative Enzymology of Phosphomonoesterases and Phosphodiesterases across the Alkaline Phosphatase Superfamily.PMID 27670607Read ↗

Cooperative Electrostatic Interactions Drive Functional Evolution in the Alkaline Phosphatase Superfamily.Semantic proximity Read ↗

QM/MM analysis suggests that Alkaline Phosphatase (AP) and nucleotide pyrophosphatase/phosphodiesterase slightly tighten the transition state for phosphate diester hydrolysis relative to solution: implication for catalytic promiscuity in the AP superfamily.Semantic proximity Read ↗

Distinct enzymic functional groups are required for the phosphomonoesterase and phosphodiesterase activities of Clostridium thermocellum polynucleotide kinase/phosphatase.Semantic proximity Read ↗

Transition States and Control of Substrate Preference in the Promiscuous Phosphatase PP1.Semantic proximity Read ↗

Shared promiscuous activities and evolutionary features in various members of the amidohydrolase superfamily.Semantic proximity Read ↗

An efficient, multiply promiscuous hydrolase in the alkaline phosphatase superfamily.Semantic proximity Read ↗

Binuclear Metallohydrolases: Complex Mechanistic Strategies for a Simple Chemical ReactionSemantic proximity Read ↗

Evolutionary Genomics of the HAD Superfamily: Understanding the Structural Adaptations and Catalytic Diversity in a Superfamily of Phosphoesterases and Allied EnzymesSemantic proximity Read ↗

Diversification of function in the haloacid dehalogenase enzyme superfamily: The role of the cap domain in hydrolytic phosphoruscarbon bond cleavage.Semantic proximity Read ↗

Probing Mechanistic Similarities between Response Regulator Signaling Proteins and Haloacid Dehalogenase Phosphatases.Semantic proximity Read ↗

Unexpected catalytic site variation in phosphoprotein phosphatase homologues of cofactor-dependent phosphoglycerate mutase.Semantic proximity Read ↗

The remarkable pliability and promiscuity of specialized metabolism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.