Article
Studying the evolutionary potential of ancestral aryl sulfatases in the alkaline phosphatase family with droplet microfluidics.
The Analyst - 17 Mar 2026
Eenink Bernard D G, Holstein Josephin M, Heberlein Magdalena, Dilkaute Carina, Jose Joachim, Hollfelder Florian, van Loo Bert, Bornberg-Bauer Erich, Kaminski Tomasz S, Lange Andreas
Abstract excerpt
Characterizing the dynamics and functional shifts during protein evolution is essential, both for understanding protein evolution and for rationalizing efficient strategies for e.g. enzymes with desired and effective functions. Most proteins organize in families, sets of divergent sequences which share a common ancestor and have a similar structural fold. Here, we study aryl sulfatases, a subfamily of the large...
Topics
- Alkaline Phosphatase
- Evolution, Molecular
- Arylsulfatases
- Microfluidics
- Mutation
- Microfluidic Analytical Techniques