Article

Human coronaviruses disassemble processing bodies

2020-11-09

Abstract excerpt

A dysregulated proinflammatory cytokine response is characteristic of severe coronavirus infections caused by SARS-CoV-2, yet our understanding of the underlying mechanism responsible for this imbalanced immune response remains incomplete. Processing bodies (PBs) are cytoplasmic membraneless ribonucleoprotein granules that control innate immune responses by mediating the constitutive decay or suppression of mRNA t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d4a21e76-15aa-5d86-bc49-283e42af3952
DOI: 10.1101/2020.11.08.372995

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human coronaviruses disassemble processing bodiesDOI 10.1101/2020.11.08.372995Read

Human coronaviruses disassemble processing bodiesSemantic proximity Read

An expanding syphilis epidemic in China: epidemiology, behavioural risk and control strategies with a focus on low-tier female sex workers and men who have sex with menSemantic proximity Read

Rapid Decay of Host Basal mRNAs During SARS-CoV-2 Infection Perturbs Host Antiviral mRNA Biogenesis and ExportSemantic proximity Read

Cytoplasmic RNA Granules and Viral InfectionSemantic proximity Read

SARS-CoV-2 nucleocapsid protein inhibits the PKR-mediated integrated stress response through RNA-binding domain N2bSemantic proximity Read

The nucleocapsid (N) proteins of different human coronaviruses demonstrate a variable capacity to induce the formation of cytoplasmic condensatesSemantic proximity Read

Virus-Induced Cytoplasmic Aggregates and Inclusions Are Critical Cellular Regulatory and Antiviral FactorsSemantic proximity Read

A truncated SARS-CoV-2 nucleocapsid protein enhances virus fitness by evading antiviral responsesSemantic proximity Read

SARS-CoV-2 nucleocapsid protein impairs stress granule formation to promote viral replicationSemantic proximity Read

Rapid decay of host basal mRNAs during SARS-CoV-2 infection perturbs host antiviral mRNA biogenesis and exportSemantic proximity Read

SARS-CoV-2 infection triggers widespread host mRNA decay leading to an mRNA export blockSemantic proximity Read

Regulation of virion production by the ORF8 signal peptide across SARS-CoV-2 variantsSemantic proximity Read