Article

SARS-CoV-2 nucleocapsid protein inhibits the PKR-mediated integrated stress response through RNA-binding domain N2b

2022-09-02

Abstract excerpt

<h4>ABSTRACT</h4> The nucleocapsid protein N of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enwraps and condenses the viral genome for packaging but is also an antagonist of the innate antiviral defense. It suppresses the integrated stress response (ISR), purportedly by interacting with stress granule (SG) assembly factors G3BP1 and 2, and inhibits type I interferon responses. To elucidate its mo...

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Literature Corpus work: 039ae2ac-285e-52fc-8345-8f982928a20b
DOI: 10.1101/2022.09.02.506332

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