Article

The ITPRIPL1- CD3ε axis: a novel immune checkpoint controlling T cells activation

2022-03-01

Abstract excerpt

The immune system is critical to fighting infections and disease. The molecular recognition of harmful entities takes place when antigen-presenting cells (APC) harboring major histocompatibility complex (MHC) molecules bound to peptides derived from harmful antigens (ligand) dock on specific T cell receptor (TCR)-CD3 complex (receptor) at the surface of CD8+ T cells. The discovery of a general immune checkpoint me...

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Literature Corpus work: d48fcb5f-ef58-5d70-a600-746b7f9fb804
DOI: 10.1101/2022.02.25.481189

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