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Article

Complex regulatory network of programmed death-ligand 1 in cancer: Cancer immunomodulation from molecular mechanisms to clinical applications

9 May 2025

Abstract excerpt

Immune checkpoint therapy targeting PD-L1/PD-1 represents a key cancer treatment strategy. PD-L1 binds PD-1 on T cells, suppressing activation and enabling tumor immune escape. Although the blockade of the PD-L1/PD-1 pathway has demonstrated significant anti-tumor effects, the overall response rate remains suboptimal in solid tumors. Therefore, understanding the molecular mechanisms underlying PD-L1 deregulation...

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PMID: 40502681
DOI: 10.1016/j.isci.2025.112615

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