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Regulatory mechanisms of PD-1/PD-L1 in cancers

18 May 2024

Abstract excerpt

Immune evasion contributes to cancer growth and progression. Cancer cells have the ability to activate different immune checkpoint pathways that harbor immunosuppressive functions. The programmed death protein 1 (PD-1) and programmed cell death ligands (PD-Ls) are considered to be the major immune checkpoint molecules. The interaction of PD-1 and PD-L1 negatively regulates adaptive immune response mainly by...

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PMID: 38762484
DOI: 10.1186/s12943-024-02023-w

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