Article

<i>RRAS</i> and <i>RRAS2</i> mutations are recurrent oncogenic drivers in lung cancer and are sensitive to the pan-RAS inhibitor RMC-6236

2025-09-21

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Introduction</h4> RRAS and RRAS2 encode a subfamily of RAS-like small GTPases that share considerable structural and functional similarities with KRAS , HRAS , and NRAS. Whether homologous RRAS / RRAS2 mutations are oncogenic and actionable drivers in lung cancer remains underexplored. <h4>Methods</h4> An institutional cohort of 8,488 non-small cell lung carcinomas (NSCLC) sequenced...

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Literature Corpus work: d48c57bf-ecdf-5bd6-ab47-08ff5c3d7177
DOI: 10.1101/2025.09.19.677259

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