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Impact of KRASG12D subtype and concurrent pathogenic mutations on advanced non-small cell lung cancer outcomes.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico - 1 Apr 2024

Caballé-Perez Enrique, Hernández-Pedro Norma, Ramos-Ramírez Maritza, Barrios-Bernal Pedro, Romero-Núñez Eunice, Lucio-Lozada José, Ávila-Ríos Santiago, Reyes-Terán Gustavo, Cardona Andrés F, Arrieta Oscar

Abstract excerpt

PURPOSE: Mutations in the Kirsten rat sarcoma viral (KRAS) oncogene constitute a significant driver of lung adenocarcinoma, present in 10-40% of patients, which exhibit heterogeneous clinical outcomes, mainly driven by concurrent genetic alterations. However, characterization of KRAS mutational subtypes and their impact on clinical outcomes in Latin America is limited. METHODS: A cohort study was conducted at the...

Topics

Female
Humans
Carcinoma, Non-Small-Cell Lung
Cohort Studies
Lung Neoplasms
Mutation
Proto-Oncogene Proteins p21(ras)

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37490263
DOI: 10.1007/s12094-023-03279-2
PMCID: PMC10981588

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