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Article

Molecular co-alteration patterns of RICTOR-mutant metastatic lung adenocarcinomas: a single-center cohort study.

Virchows Archiv : an international journal of pathology - 1 Jul 2026

Ozata Mehmet Berkay, Aytac Ali, Erdogdu Ibrahim Halil, Alkan Ali, Tanriverdi Ozgur

Abstract excerpt

RICTOR, a core component of the mTORC2 complex, regulates AKT signaling and has been implicated in tumor biology. While RICTOR amplification and overexpression have been reported, the mutational landscape of RICTOR and its molecular context in non-small cell lung cancer (NSCLC) remain insufficiently characterized. This study aimed to describe the prevalence and co-alteration patterns of RICTOR mutations in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41201553
DOI: 10.1007/s00428-025-04329-6

Genes

RICTOR
EGFR
KRAS
TP53
ALK
BRAF
EML4
KEAP1
PIK3CA
ROS1
STK11

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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