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Article

Characterization of KRAS Mutation Subtypes in Non-small Cell Lung Cancer.

Molecular cancer therapeutics - 1 Dec 2021

Judd Julia, Abdel Karim Nagla, Khan Hina, Naqash Abdul Rafeh, Baca Yasmine, Xiu Joanne, VanderWalde Ari M, Mamdani Hirva, Raez Luis E, Nagasaka Misako, Pai Sachin Gopalkrishna, Socinski Mark A, Nieva Jorge J, Kim Chul, Wozniak Antoinette J, Ikpeazu Chukwuemeka, de Lima Lopes Gilberto, Spira Alexander I, Korn W Michael, Kim Edward S, Liu Stephen V, Borghaei Hossein

Abstract excerpt

KRAS is the most commonly mutated oncogene in NSCLC and development of direct KRAS inhibitors has renewed interest in this molecular variant. Different KRAS mutations may represent a unique biologic context with different prognostic and therapeutic impact. We sought to characterize genomic landscapes of advanced, KRAS-mutated non-small cell lung cancer (NSCLC) in a large national cohort to help guide future...

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Identifiers

PMID: 34518295
DOI: 10.1158/1535-7163.MCT-21-0201
PMCID: PMC9662933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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