Article
Clinicopathologic features of KRAS G12C-mutated non-small cell lung carcinomas:insights from 279 retrospective cases.
Virchows Archiv : an international journal of pathology - 1 Jul 2026
Bradová Martina, Slavík Petr, Vaněček Tomáš, Martínek Petr, Grossmann Petr, Kormunda Stanislav, Behenská Kristýna, Svatoň Martin, Pešek Miloš, Jirásek Tomáš, Špůrková Zuzana, Hroudová Petra, Mrázková Hana, Hořavová Barbora, Roubec Jaromír, Baník Martin, Mukenšnábl Petr, Michal Michal, Švajdler Marián
Abstract excerpt
KRAS G12C-mutated non-small cell lung carcinoma (NSCLC), caused by a glycine-to-cysteine substitution at codon 12, is associated with poor prognosis and is now targetable with specific inhibitors. We retrospectively analyzed 279 KRAS G12C-mutated NSCLC cases (2017-2023) from our registry with available histologic, immunohistochemical, and molecular data. The cohort included 279 patients (125 females, 151 males;...
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