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Article

Prognostic significance of RICTOR mutations in EGFR-mutant metastatic lung adenocarcinoma: a retrospective cohort study.

Virchows Archiv : an international journal of pathology - 1 Jul 2026

Aytac Ali, Ozata Berkay Mehmet, Erdogdu Ibrahim Halil, Alkan Ali, Tanriverdi Ozgur

Abstract excerpt

RICTOR, a scaffold protein of the mTORC2 complex, regulates AKT signaling and has been implicated in tumor progression and therapy resistance across multiple cancers. However, the prognostic impact of RICTOR mutations in epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma remains unclear. This study aimed to evaluate the clinicopathological, molecular, and survival characteristics of patients with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42080921
DOI: 10.1007/s00428-026-04559-2
PMCID: PMC13369718

Genes

RICTOR
EGFR
ALK
BRAF
KRAS
MET
RET
ROS1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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