Article

Hypoxic memory of tumor intrinsic type I interferon suppression promotes breast cancer metastasis

2022-05-13

Abstract excerpt

Hypoxia is a common feature of many solid tumors due to aberrant proliferation and angiogenesis and has been associated with tumor progression and metastasis. Most of the well-known hypoxia effects are mediated through hypoxia-inducible factors (HIFs), but the long-lasting effect of hypoxia beyond the immediate HIF regulation remains less understood. Here we show that hypoxia exerts a prolonged effect to promote m...

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Literature Corpus work: d45cb989-b2fc-52b7-830f-69fc2a70d83d
DOI: 10.1101/2022.05.12.491632

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