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Article

Intermittent hypoxia induces a metastatic phenotype in breast cancer.

Oncogene - 1 Aug 2018

Chen Anna, Sceneay Jaclyn, Gödde Nathan, Kinwel Tanja, Ham Sunyoung, Thompson Erik W, Humbert Patrick O, Möller Andreas

Abstract excerpt

Hypoxia arises frequently in solid tumors and is a poor prognostic factor as it promotes tumor cell proliferation, invasion, angiogenesis, therapy resistance, and metastasis. Notably, there are two described forms of hypoxia present in a growing tumor: chronic hypoxia, caused by abnormal tumor vasculature, and intermittent hypoxia, caused by transient perfusion facilitated by tumor-supplying blood vessels. Here,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29713057
DOI: 10.1038/s41388-018-0259-3

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