Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypoxia acts as an environmental cue for the human tissue-resident memory T cell differentiation program

23 May 2021

Abstract excerpt

Tissue-resident memory T cells (TRM) provide frontline defense against infectious diseases and contribute to antitumor immunity; however, aside from the necessity of TGF-β, knowledge regarding TRM-inductive cues remains incomplete, particularly for human cells. Oxygen tension is an environmental cue that distinguishes peripheral tissues from the circulation, and here, we demonstrate that differentiation of human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34027895
DOI: 10.1172/jci.insight.138970

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypoxia acts as an environmental cue for the human tissue-resident memory T cell differentiation programPMID 34027895Read ↗

Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites.Semantic proximity Read ↗

Axes of heterogeneity in human tissue-resident memory T cells.Semantic proximity Read ↗

Functional Heterogeneity and Therapeutic Targeting of Tissue-Resident Memory T Cells.Semantic proximity Read ↗

Hypoxia induces dichotomous and reversible attenuation of T cell responses through reactive oxygen species-dependent phenotype redistribution and delay in lymphoblast proliferation.Semantic proximity Read ↗

Tissue-resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance.Semantic proximity Read ↗

Resident Memory T Cells and Their Effect on CancerSemantic proximity Read ↗

Tissue-resident memory CAR T cells with stem-like characteristics display enhanced efficacy against solid and liquid tumorsSemantic proximity Read ↗

Chronic hypoxia reprograms human immature dendritic cells by inducing a proinflammatory phenotype and TREM-1 expression.Semantic proximity Read ↗

<scp>H</scp>uman<scp> CD4</scp><sup><scp>+</scp></sup><scp> T </scp>cells maintain specific functions even under conditions of extremely restricted<scp> ATP</scp> productionSemantic proximity Read ↗

Effector T Cells under Hypoxia have an Altered Transcriptome Similar to Tumor-Stressed T Cells Found in Non-Responsive Melanoma PatientsSemantic proximity Read ↗

Tumor-Associated Macrophages and Their Functional Transformation in the Hypoxic Tumor MicroenvironmentSemantic proximity Read ↗

Human intestinal tissue-resident memory CD8+ T cells comprise transcriptionally and functionally distinct subsetsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.