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Article

Hypoxia Signaling in Cancer: From Basics to Clinical Practice

3 May 2021

Abstract excerpt

Cancer hypoxia, recognized as one of the most important hallmarks of cancer, affects gene expression, metabolism and ultimately tumor biology-related processes. Major causes of cancer hypoxia are deficient or inappropriate vascularization and systemic hypoxia of the patient (frequently induced by anemia), leading to a unique form of genetic reprogramming by hypoxia induced transcription factors (HIF). However,...

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PMID: 34257622
DOI: 10.3389/pore.2021.1609802

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