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Article

Light chain mutations contribute to defining the fibril morphology in systemic AL amyloidosis.

Nature communications - 15 Jun 2024

Karimi-Farsijani Sara, Pfeiffer Peter Benedikt, Banerjee Sambhasan, Baur Julian, Kuhn Lukas, Kupfer Niklas, Hegenbart Ute, Schönland Stefan O, Wiese Sebastian, Haupt Christian, Schmidt Matthias, Fändrich Marcus

Abstract excerpt

Systemic AL amyloidosis is one of the most frequently diagnosed forms of systemic amyloidosis. It arises from mutational changes in immunoglobulin light chains. To explore whether these mutations may affect the structure of the formed fibrils, we determine and compare the fibril structures from several patients with cardiac AL amyloidosis. All patients are affected by light chains that contain an IGLV3-19 gene...

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Identifiers

PMID: 38879609
DOI: 10.1038/s41467-024-49520-6
PMCID: PMC11180120

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