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Article

Structural localization of disease-associated sequence variations in the NACHT and LRR domains of PYPAF1 and NOD2.

FEBS letters - 20 Nov 2003

Albrecht Mario, Domingues Francisco S, Schreiber Stefan, Lengauer Thomas

Abstract excerpt

Several autoinflammatory diseases with distinct clinical manifestations have been associated with sequence variations in the gene products PYPAF1/CIAS1 and NOD2/CARD15. Both proteins belong to the PYD/CARD-containing family of apoptosis regulators and activators of pro-inflammatory caspases. To gain insight into the dysfunctional role of sequence alterations, we assembled a structure-based multiple sequence...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14623123
DOI: 10.1016/s0014-5793(03)01222-5

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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