Article

Structural Insight into the Function of Human Peptidyl Arginine Deiminase 6

2024-06-10

Abstract excerpt

Peptidyl arginine deiminase 6 (PADI6) is vital for early embryonic development in mice and humans, yet its function remains elusive. PADI6 is less conserved than other PADIs and it is currently unknown whether it has a catalytic function. Here we have shown that human PADI6 dimerises like hPADIs 2-4, however, does not bind Ca 2+ and is inactive in in vitro assays against standard PADI substrates. By determining...

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Identifiers and source

Literature Corpus work: 1625917a-c89d-5aae-90d4-1190868ca584
DOI: 10.1101/2024.06.10.598250

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