Article

Generation of a Mouse Model Lacking the Non-Homologous End-Joining Factor Mri/Cyren

2019-11-24

Abstract excerpt

Classical non-homologous end joining (NHEJ) is a molecular pathway that detects, processes and ligates DNA double-strand breaks (DSBs) throughout the cell cycle. Mutations in several NHEJ genes result in neurological abnormalities and immunodeficiency both in humans and mice. The NHEJ pathway is required for the V(D)J recombination in developing B and T lymphocytes, and for class switch recombination in mature B c...

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Literature Corpus work: d421a2bb-756e-50e1-982b-27f4bd6f52b7
DOI: 10.20944/preprints201911.0292.v1

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