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Article

Generation of a Mouse Model Lacking the Non-Homologous End-Joining Factor Mri/Cyren

28 Nov 2019

Abstract excerpt

Classical non-homologous end joining (NHEJ) is a molecular pathway that detects, processes, and ligates DNA double-strand breaks (DSBs) throughout the cell cycle. Mutations in several NHEJ genes result in neurological abnormalities and immunodeficiency both in humans and mice. The NHEJ pathway is required for V(D)J recombination in developing B and T lymphocytes, and for class switch recombination in mature B...

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PMID: 31795137
DOI: 10.3390/biom9120798

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