Article

Selective IL13Rα2-Targeted Functionality of IL13-Ligand CARs is Enhanced by Inclusion of 4-1BB Co-Stimulation

2022-03-30

Abstract excerpt

<h4> ABSTRACT </h4> Chimeric antigen receptor (CAR) T cell immunotherapy is emerging as a powerful strategy for cancer therapy; however, an important safety consideration is the potential for off-tumor recognition of normal tissue. This is particularly important as ligand-based CARs are optimized for clinical translation. Our group has developed and clinically translated an IL13(E12Y) ligand- based CAR targeting...

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Literature Corpus work: d4078012-ac3b-5c3d-b39d-aed377dec6a5
DOI: 10.1101/2022.03.30.486439

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