Article
A novel ligand delivery system to non-invasively visualize and therapeutically exploit the IL13Rα2 tumor-restricted biomarker.
Neuro-oncology - 1 Oct 2012
Nguyen Van, Conyers Jesse M, Zhu Dongqin, Gibo Denise M, Hantgan Roy R, Larson Steven M, Debinski Waldemar, Mintz Akiva
Abstract excerpt
Our objective was to exploit a novel ligand-based delivery system for targeting diagnostic and therapeutic agents to cancers that express interleukin 13 receptor alpha 2 (IL13Rα2), a tumor-restricted plasma membrane receptor overexpressed in glioblastoma multiforme (GBM), meningiomas, peripheral nerve sheath tumors, and other peripheral tumors. On the basis of our prior work, we designed a novel IL13Rα2-targeted...
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