Article
Dynamic Pneumococcal Genetic Adaptations Support Bacterial Growth and Inflammation during Coinfection with Influenza.
Infection and immunity - 16 Jun 2021
Smith Amanda P, Lane Lindey C, van Opijnen Tim, Woolard Stacie, Carter Robert, Iverson Amy, Burnham Corinna, Vogel Peter, Roeber Dana, Hochu Gabrielle, Johnson Michael D L, McCullers Jonathan A, Rosch Jason, Smith Amber M
Abstract excerpt
Streptococcus pneumoniae (pneumococcus) is one of the primary bacterial pathogens that complicates influenza virus infections. These bacterial coinfections increase influenza-associated morbidity and mortality through a number of immunological and viral-mediated mechanisms, but the specific bacterial genes that contribute to postinfluenza pathogenicity are not known. Here, we used genome-wide transposon...
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