Article

From the Structural and (Dys)function of ATP Synthase to Deficiency in Age-Related Diseases

2022-02-18

Abstract excerpt

The ATP synthase is a mitochondrial complex embedded in the inner mitochondrial membrane. The enzyme is under the double genetic control of the mitochondrial DNA (mtDNA) and nuclear DNA (nDNA). Fatal human diseases have been associated with defects in ATP synthase (Complex V) activity linked to mtDNA or nDNA pathogenetic variants in genes encoding structural subunits or assembly factors. Mitochondrial post-transla...

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Literature Corpus work: 2fe30d7d-c5df-564a-a836-0d41c3fc9fbd
DOI: 10.20944/preprints202202.0219.v1

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