Article

The unfolded protein response and its potential role in Huntington's disease elucidated by a systems biology approach

2016-03-02

Abstract excerpt

Huntington ́s disease (HD) is a progressive, neurodegenerative disease with a fatal outcome. Although the disease-causing gene (huntingtin) has been known for over 20 years, the exact mechanisms leading to neuronal cell death are still controversial. One potential mechanism contributing to the massive loss of neurons observed in the brain of HD patients could be the unfolded protein response (UPR) activated by acc...

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Literature Corpus work: 5cae09bc-bfb5-539d-be8d-0d19598e25ea
DOI: 10.12688/f1000research.6358.2

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