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Finerenone ameliorates diabetic renal fibrosis via KRAS/FOXM1/SEMA3C signaling pathway in mesangial cells

2025-12-11

Abstract excerpt

<h4>Background: </h4> and Purpose: Hyperactivation of the mineralocorticoid receptor (MR) causes pro-inflammatory and pro-fibrotic actions, which are potential therapeutic targets of diabetic kidney disease (DKD). Finerenone (FIN), a novel non-steroidal mineralocorticoid receptor antagonist, attenuates vascular endothelial cell fibrosis in diabetic kidneys, but the precise mechanism remains unclear. Present study...

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Literature Corpus work
d3bea3ef-cfb8-5ad4-ad8e-94e1069163f9
DOI
10.22541/au.176545938.83190905/v1
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