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Rhein reversal of DNA hypermethylation-associated Klotho suppression ameliorates renal fibrosis in mice

5 Oct 2016

Abstract excerpt

Renal fibrosis is the hallmark of chronic kidney diseases (CKD) and its development and progression are significantly affected by epigenetic modifications. Rhein, a plant-derived anthraquinone, displays strong anti-fibrosis properties, but its protective mode of action remains incompletely understood. Here we explore the mechanism of Rhein anti-renal fibrosis by investigating its regulation of Klotho, a known...

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PMID: 27703201
DOI: 10.1038/srep34597

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