miR-299a-5p is a novel mediator of fibrosis in diabetic kidney disease through its regulation of antifibrotic proteins follistatin and cripto-1

Abstract excerpt

<title>Abstract</title> <p> Glomerular extracellular matrix protein accumulation, mediated largely by mesangial cells, is a defining feature of early diabetic kidney disease. Previously we showed that TGFβ1, a profibrotic cytokine with a well-defined pathogenic role in kidney fibrosis, inhibits expression of the antifibrotic follistatin through induction of microRNA-299a-5p. Whether this microRNA contributes to...

Topics

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• Collagen Type I
• Collagen Type IV
• Diabetes Mellitus, Experimental
• Diabetic Nephropathies
• Fibrosis
• Smad2 Protein
• Smad3 Protein
• Streptozocin

Identifiers and source

Literature Corpus work

f6d4e79c-bb36-50b7-a200-a6571cc2e13b

DOI

10.21203/rs.3.rs-5419387/v1