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Unlocking the therapeutic potential of lncRNA FENDRR in DCM: novel targets and insights via the miR-296-5p/HMGA1 axis

31 May 2025

Abstract excerpt

BACKGROUND: Long non-coding RNA (lncRNA) holds considerable promise in mitigating the onset and progression of diabetic cardiomyopathy (DCM). FENDRR was selected due to its reported involvement in cardiac apoptosis and inflammatory regulation, key pathways in DCM pathogenesis. This study investigated role and underlying mechanisms of FENDRR in DCM. METHODS: Type 2 diabetes mellitus (T2DM) patients were included...

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PMID: 40450345
DOI: 10.1186/s13019-025-03477-9

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