Article

PNPLA3 I148M Reduces Hepatic Triacylglycerol Secretion and Mitigates Left Ventricular Diastolic Dysfunction in MASH Diet Mice

2025-04-27

Abstract excerpt

<h4>ABSTRACT</h4> Cardiovascular disease (CVD) is a leading cause of mortality among individuals with metabolic dysfunction-associated steatotic liver disease (MASLD). Paradoxically, the strongest genetic risk factor for MASLD, PNPLA3-I148M, is associated with a reduced risk of CVD. The mechanisms for how PNPLA3-I148M causes MASLD and preserves cardiac health are not well understood. To further investigate cardio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d3ad8462-29aa-5b81-9ad8-21565767aca4
DOI: 10.1101/2025.04.24.650494

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PNPLA3 I148M Reduces Hepatic Triacylglycerol Secretion and Mitigates Left Ventricular Diastolic Dysfunction in MASH Diet MiceDOI 10.1101/2025.04.24.650494Read

Function of PNPLA3 I148M-Lessons From In Vivo Studies in Humans.Semantic proximity Read

Substrate-Specific Function of PNPLA3 Facilitates Hepatic VLDL-Triglyceride Secretion During Stimulated LipogenesisSemantic proximity Read

Tissue-specific regulation of PNPLA3 promotes lipid remodeling in response to dietary and environmental challengesSemantic proximity Read

The fatty liver disease-causing protein PNPLA3-I148M alters lipid droplet-Golgi dynamicsSemantic proximity Read

Identification of a Metabolic, Transcriptomic, and Molecular Signature of Patatin-Like Phospholipase Domain Containing 3-Mediated Acceleration of Steatohepatitis.Semantic proximity Read

Targeting PNPLA3 to Treat MASH and MASH Related Fibrosis and Cirrhosis.Semantic proximity Read

Circulating triacylglycerol signatures in nonalcoholic fatty liver disease associated with the I148M variant in PNPLA3 and with obesity.Semantic proximity Read

Impact of PNPLA3 I148M on alpha-1 antitrypsin deficiency-dependent liver disease progression.Semantic proximity Read

Experimental Models to Investigate PNPLA3 in Liver Steatosis.Semantic proximity Read

PNPLA3-I148M is a Neomorph that Interferes with Two Primary Hepatic Triglyceride Clearance PathwaysSemantic proximity Read

The PNPLA3 variant I148M reveals protective effects toward hepatocellular carcinoma in mice via restoration of omega-3 polyunsaturated fats.Semantic proximity Read

Human hepatocyte PNPLA3 148M exacerbates rapid non-alcoholic steatohepatitis development in chimeric miceSemantic proximity Read