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Article

Circulating triacylglycerol signatures in nonalcoholic fatty liver disease associated with the I148M variant in PNPLA3 and with obesity.

Diabetes - 1 Jan 2014

Hyysalo Jenni, Gopalacharyulu Peddinti, Bian Hua, Hyötyläinen Tuulia, Leivonen Marja, Jaser Nabil, Juuti Anne, Honka Miikka-Juhani, Nuutila Pirjo, Olkkonen Vesa M, Oresic Matej, Yki-Järvinen Hannele

Abstract excerpt

We examined whether relative concentrations of circulating triacylglycerols (TAGs) between carriers compared with noncarriers of PNPLA3(I148M) gene variant display deficiency of TAGs, which accumulate in the liver because of defective lipase activity. We also analyzed the effects of obesity-assoc...

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Source

Identifiers

PMID: 24009255
DOI: 10.2337/db13-0774

Genes

PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24009255-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Circulating triacylglycerol signatures in nonalcoholic fatty liver disease associated with the I148M variant in PNPLA3 and with obesity.PMID 24009255Read ↗

The PNPLA3-I148M variant increases polyunsaturated triglycerides in human adipose tissue.Semantic proximity Read ↗

I148M variant in PNPLA3 reduces central adiposity and metabolic disease risks while increasing nonalcoholic fatty liver disease.Semantic proximity Read ↗

PNPLA3 variant I148M is associated with altered hepatic lipid composition in humans.Semantic proximity Read ↗

PNPLA3 I148M variant in nonalcoholic fatty liver disease: demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis.Semantic proximity Read ↗

Function of PNPLA3 I148M-Lessons From In Vivo Studies in Humans.Semantic proximity Read ↗

PNPLA3 I148M Polymorphism in Patients with Nonalcoholic Fatty Liver Disease, Obesity and Prediabetes.Semantic proximity Read ↗

The PNPLA3 I148M polymorphism is associated with insulin resistance and nonalcoholic fatty liver disease in a normoglycaemic population.Semantic proximity Read ↗

I148M variant of PNPLA3 increases the susceptibility to non-alcoholic fatty liver disease caused by obesity and metabolic disorders.Semantic proximity Read ↗

The fatty liver disease-causing protein PNPLA3-I148M alters lipid droplet-Golgi dynamicsSemantic proximity Read ↗

PNPLA3-associated steatohepatitis: toward a gene-based classification of fatty liver disease.Semantic proximity Read ↗

PNPLA3 as a therapeutic target for fatty liver disease: the evidence to date.Semantic proximity Read ↗

Healthy PNPLA3 risk allele carriers present with unexpected body fat composition. A study of one thousand subjects.Semantic proximity Read ↗

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