Exercise-associated epigenetic remodeling and TCR repertoire dynamics in Lynch syndrome carriers

Abstract excerpt

Lynch syndrome (LS) carriers are at elevated cancer risk. Emerging evidence suggests that exercise may serve as a non-pharmacologic preventive strategy, yet the epigenetic and immunological mechanisms underlying its protective effects in this population remain unclear. Here, we perform integrative multi-omics profiling of DNA methylation, gene expression, and the T cell receptor (TCR) repertoire in LS carriers und...

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• Genetic factors in colorectal cancer
• Genetic Neurodegenerative Diseases
• Nuclear Structure and Function

Identifiers and source

Literature Corpus work

d3987a59-173e-5d9b-ab96-862396773fb2

DOI

10.1016/j.isci.2026.117364