Article

Exercise-associated epigenetic remodeling and TCR repertoire dynamics in Lynch syndrome carriers

2026-08-28

Abstract excerpt

Lynch syndrome (LS) carriers are at elevated cancer risk. Emerging evidence suggests that exercise may serve as a non-pharmacologic preventive strategy, yet the epigenetic and immunological mechanisms underlying its protective effects in this population remain unclear. Here, we perform integrative multi-omics profiling of DNA methylation, gene expression, and the T cell receptor (TCR) repertoire in LS carriers und...

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Literature Corpus work: d3987a59-173e-5d9b-ab96-862396773fb2
DOI: 10.1016/j.isci.2026.117364

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