Systemic immune activation in hereditary cancer predisposition syndromes: a cross-sectional study.

doi:10.1186/s12916-026-05188-x

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Article

Systemic immune activation in hereditary cancer predisposition syndromes: a cross-sectional study.

BMC medicine - 25 Aug 2026

Kelemen István, Horti-Oravecz Klaudia, Bozsik Anikó, Pócza Tímea, Papp János, Likó István, Neuperger Patrícia, Balogh Fanni, Kemény Ágnes, Nagy Petra, Vereczki Viktória, Pósa Szonja Polett, Pongor Lőrinc Sándor, Kövesdi Dorottya, Butz Henriett, Patócs Attila, Szebeni Gábor János, Grolmusz Vince Kornél

Abstract excerpt

BACKGROUND: Immune surveillance mechanisms contribute to the elimination of precancerous lesions in hereditary cancer predisposition syndromes (HCPSs). METHODS: By combining single-cell transcriptomics, multiparametric mass cytometry and cytokine profiling of the systemic immune environment in 391 individuals among whom 227 are living with HCPSs we investigated phenotypic alterations in cancer-free individuals...

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PMID: 42665817
DOI: 10.1186/s12916-026-05188-x
PMCID: PMC13523197

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BRCA1

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