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Aerobic exercise training resets the human skeletal muscle methylome 10 years after breast cancer treatment and survival

21 Dec 2022

Abstract excerpt

Cancer survivors suffer impairments in skeletal muscle in terms of reduced mass and function. Interestingly, human skeletal muscle possesses an epigenetic memory of earlier stimuli, such as exercise. Long-term retention of epigenetic changes in skeletal muscle following cancer survival and/or exercise training has not yet been studied. We, therefore, investigated genome-wide DNA methylation (methylome) in...

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PMID: 36542473
DOI: 10.1096/fj.202201510rr

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