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Article

Protein level variability determines phenotypic heterogeneity in proteotoxic stress response.

The FEBS journal - 1 Dec 2020

Guilbert Marie, Anquez François, Pruvost Alexandra, Thommen Quentin, Courtade Emmanuel

Abstract excerpt

Cell-to-cell variability in stress response is a bottleneck for the construction of accurate and predictive models which could guide clinical diagnosis and treatment of certain diseases, for example, cancer. Indeed, such phenotypic heterogeneity can lead to fractional killing and persistence of a subpopulation of cells which are resistant to a given treatment. The heat shock response network plays a major role in...

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Identifiers

PMID: 32222033
DOI: 10.1111/febs.15297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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