Article
Transcriptome States Reflect Imaging of Aging States.
The journals of gerontology. Series A, Biological sciences and medical sciences - 14 Jun 2018
Eckley D Mark, Coletta Christopher E, Orlov Nikita V, Wilson Mark A, Iser Wendy, Bastian Paul, Lehrmann Elin, Zhang Yonqing, Becker Kevin G, Goldberg Ilya G
Abstract excerpt
In this study, we describe a morphological biomarker that detects multiple discrete subpopulations (or "age-states") at several chronological ages in a population of nematodes (Caenorhabditis elegans). We determined the frequencies of three healthy adult states and the timing of the transitions between them across the lifespan. We used short-lived and long-lived strains to confirm the general applicability of the...
Topics
- Aging
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Gene Expression Profiling
- Genes, Helminth
- Genetic Markers
- HSP70 Heat-Shock Proteins
- Heat-Shock Proteins, Small
- Longevity