Article

AMPK activation by metformin promotes survival of dormant ER+ breast cancer cells

2020-01-28

Abstract excerpt

<h4>Purpose</h4> Despite adjuvant anti-estrogen therapy for patients with estrogen receptor alpha (ER)-positive breast cancer, dormant residual disease can persist for years and eventually cause tumor recurrence. We sought to deduce mechanisms underlying the persistence of dormant cancer cells to identify therapeutic strategies. <h4>Experimental Design</h4> Mimicking the aromatase inhibitor-induced depletion of...

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Literature Corpus work: d665dc10-3926-577b-b27e-0a2f3030e3ca
DOI: 10.1101/2020.01.21.914382

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