Article

Energy Expenditure during Cell Spreading Regulates the Stem Cells Responses to Matrix Stiffness

2019-11-23

Abstract excerpt

Cells respond to the mechanical properties of the extracellular matrix (ECM) through formation of focal adhesions (FAs), re-organization of the actin cytoskeleton and adjustment of cell contractility. These are energy-demanding processes, but a potential causality between mechanical cues (matrix stiffness) and cellular (energy) metabolism remains largely unexplored. Here, we culture human mesenchymal stem cells (h...

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Literature Corpus work: 6f6e23af-4509-51ea-86ac-2c65c9ef1335
DOI: 10.1101/852400

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