Article

DNA polymerase kappa stabilized by PTBP2 interacts with MRE11 and promotes genomic instability in leukemia cells

2024-08-19

Abstract excerpt

Polypyrimidine tract binding protein 2 (PTBP2) is an RNA-binding protein that controls alternative splicing in neuronal, muscle, and Sertoli cells. Our study unveils a novel role of PTBP2 in promoting the excessive production of the DNA polymerase kappa ( Pol κ ) by stabilizing its 3’UTR. We observed an association between its increased expression and the upregulation of PTBP2 in clinical samples of Chronic Myelo...

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Literature Corpus work: d376c48e-3215-5512-bfe0-178e8e9d134e
DOI: 10.1101/2024.08.18.608437

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