Article

Nucleotide excision repair deficiency is a targetable therapeutic vulnerability in clear cell renal cell carcinoma

2023-02-07

Abstract excerpt

<h4>Purpose</h4> Due to a demonstrated lack of DNA repair deficiencies, clear cell renal cell carcinoma (ccRCC) has not benefitted from targeted synthetic lethality-based therapies. We investigated whether nucleotide excision repair (NER) deficiency is present in an identifiable subset of ccRCC cases that would render those tumors sensitive to therapy targeting this specific DNA repair pathway aberration. <h4>Exp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d36114d4-9c7d-5a76-a553-f636c3ef6230
DOI: 10.1101/2023.02.07.527498

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nucleotide excision repair deficiency is a targetable therapeutic vulnerability in clear cell renal cell carcinomaDOI 10.1101/2023.02.07.527498Read

Identification of a Synthetic Lethal Relationship between Nucleotide Excision Repair Deficiency and Irofulven Sensitivity in Urothelial CancerSemantic proximity Read

ERCC2 Helicase Domain Mutations Confer Nucleotide Excision Repair Deficiency and Drive Cisplatin Sensitivity in Muscle-Invasive Bladder CancerSemantic proximity Read

Targeting Germline- and Tumor-Associated Nucleotide Excision Repair Defects in CancerSemantic proximity Read

Identification of an <i>ERCC2</i> mutation associated mutational signature of nucleotide excision repair deficiency in targeted panel sequencing dataSemantic proximity Read

Exosome component 1 cleaves single-stranded DNA and sensitizes kidney renal clear cell carcinoma cells to poly(ADP-ribose) polymerase inhibitorSemantic proximity Read

Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors.Semantic proximity Read

Bioinformatics analysis of ERCC family in pan-cancer and ERCC2 in bladder cancer.Semantic proximity Read

Deficiency of nucleotide excision repair explains mutational signature observed in cancerSemantic proximity Read

XPA tumor variants lead to defects in NER that sensitize cells to cisplatinSemantic proximity Read

A new multisystem ERCC1-hepatorenal syndrome: insights from a clinical cohort, molecular pathogenesis, and management guidelines.Semantic proximity Read

Eukaryotic nucleotide excision repair: from understanding mechanisms to influencing biology.Semantic proximity Read

Essential genetic mutations impair DNA damage repair and modulate tumor immune microenvironment in ccRCC.Semantic proximity Read