Article

Identification of an <i>ERCC2</i> mutation associated mutational signature of nucleotide excision repair deficiency in targeted panel sequencing data

2026-02-19

Abstract excerpt

Next generation sequencing based mutational signatures are frequently used to identify tumors with specific DNA repair deficiencies for targeted therapeutic strategies. Although mutational signatures are most commonly derived from whole exome (WES) or whole genome sequencing (WGS) data, more patients currently undergo tumor sequencing using more limited targeted panels that typically encompass several hundred canc...

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Literature Corpus work: 407b6e1f-190d-5b73-b799-51e73b2efd67
DOI: 10.64898/2026.02.17.706196

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