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Article

Bioinformatics analysis of ERCC family in pan-cancer and ERCC2 in bladder cancer.

Frontiers in immunology - 1 Jan 2024

Zhang Siyang, Guan Zhenghui, Xia Qiangqiang, Shen Chong, Hu Hailong, Wang Jiangping

Abstract excerpt

Background: Single nucleotide polymorphisms (SNPs) in DNA repair genes can impair protein function and hinder DNA repair, leading to genetic instability and increased cancer risk. The Excision Repair Cross-Complementation (ERCC) family plays a crucial role in nucleotide excision repair, yet their comprehensive multi-omics characterization and roles in tumor prognosis and immune microenvironment remain unexplored....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39192988
DOI: 10.3389/fimmu.2024.1402548
PMCID: PMC11347307

Genes

ERCC2
CCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Bioinformatics analysis of ERCC family in pan-cancer and ERCC2 in bladder cancer.PMID 39192988Read ↗

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Identification of an <i>ERCC2</i> mutation associated mutational signature of nucleotide excision repair deficiency in targeted panel sequencing dataSemantic proximity Read ↗

ERCC2 mutations alter the genomic distribution pattern of somatic mutations and are independently prognostic in bladder cancer.Semantic proximity Read ↗

ERCC3 Gene Associated with Breast Cancer: A Genetic and Bioinformatic Study.Semantic proximity Read ↗

Association between the ERCC2 Asp312Asn polymorphism and risk of cancer.Semantic proximity Read ↗

ERCC2 Helicase Domain Mutations Confer Nucleotide Excision Repair Deficiency and Drive Cisplatin Sensitivity in Muscle-Invasive Bladder CancerSemantic proximity Read ↗

Meta-analysis reveals no significant association between ERCC6 polymorphisms and bladder cancer risk.Semantic proximity Read ↗

Inter-individual variation in nucleotide excision repair pathway is modulated by non-synonymous polymorphisms in ERCC4 and MBD4 genes.Semantic proximity Read ↗

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Comprehensive pathway-based interrogation of genetic variations in the nucleotide excision DNA repair pathway and risk of bladder cancer.Semantic proximity Read ↗

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