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Article

Quantitative proteomic analysis of Parkin substrates in Drosophila neurons.

Molecular neurodegeneration - 11 Apr 2017

Martinez Aitor, Lectez Benoit, Ramirez Juanma, Popp Oliver, Sutherland James D, Urbé Sylvie, Dittmar Gunnar, Clague Michael J, Mayor Ugo

Abstract excerpt

BACKGROUND: Parkin (PARK2) is an E3 ubiquitin ligase that is commonly mutated in Familial Parkinson's Disease (PD). In cell culture models, Parkin is recruited to acutely depolarised mitochondria by PINK1. PINK1 activates Parkin activity leading to ubiquitination of multiple proteins, which in turn promotes clearance of mitochondria by mitophagy. Many substrates have been identified using cell culture models in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28399880
DOI: 10.1186/s13024-017-0170-3
PMCID: PMC5387213

Genes

PINK1
STX5
VPS35

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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