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Article

Saposin C protects glucocerebrosidase against α-synuclein inhibition.

Biochemistry - 15 Oct 2013

Yap Thai Leong, Gruschus James M, Velayati Arash, Sidransky Ellen, Lee Jennifer C

Abstract excerpt

Mutations in GBA1, the gene for glucocerebrosidase (GCase), are genetic risk factors for Parkinson disease (PD). α-Synuclein (α-Syn), a protein implicated in PD, interacts with GCase and efficiently inhibits enzyme activity. GCase deficiency causes the lysosomal storage disorder Gaucher disease (GD). We show that saposin C (Sap C), a protein vital for GCase activity in vivo, protects GCase against α-syn...

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Source

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Identifiers

PMID: 24070323
DOI: 10.1021/bi401191v
PMCID: PMC3833811

Genes

GBA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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