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Article

Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult.

Neuron - 4 Mar 2020

Henderson Michael X, Sedor Samantha, McGeary Ian, Cornblath Eli J, Peng Chao, Riddle Dawn M, Li Howard L, Zhang Bin, Brown Hannah J, Olufemi Modupe F, Bassett Danielle S, Trojanowski John Q, Lee Virginia M Y

Abstract excerpt

Mutations in the GBA1 gene are the most common genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). GBA1 encodes the lysosomal lipid hydrolase glucocerebrosidase (GCase), and its activity has been linked to accumulation of α-synuclein. The current study systematically examines the relationship between GCase activity and both pathogenic and non-pathogenic forms of α-synuclein in...

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Identifiers

PMID: 31899072
DOI: 10.1016/j.neuron.2019.12.004
PMCID: PMC7060125

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